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Research

Publications

33 peer-reviewed publications. Free full text links to PubMed Central where available, otherwise to the PubMed abstract. Click Cite to download a RIS file.

33 publications ORCID 0000-0003-2841-0338 ↗ About & CV →

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2026

  1. Shih ECC, Tsai DHT, Lin SJ, Chen YY, Li TF, Lai ECC. Novel weighing approach for improved management of methadone stock inventory. Substance Abuse Treatment, Prevention, and Policy. 2026 Aug 20.

    DOI ↗

  2. Lee WJA, Tsai DHT, Lai ECC. Real-world safety of aflibercept 8 mg in neovascular age-related macular degeneration. Naunyn-Schmiedeberg's Archives of Pharmacology. 2026 Aug 11.

    PubMed ↗ DOI ↗ JCR ↗

  3. Tsai DHT, Yang ASH, Wong ZX, Chuang ATM, Cheng MCY, Shen CY, Shao SC, Lai ECC. Methodological considerations of suicide risk following antipsychotic therapy in treatment-resistant depression. British Journal of Psychiatry. 2026 Jun 25:1.

    PubMed ↗ DOI ↗ JCR ↗

  4. Lee WJA, Tsai DHT, Cheng MCY, Lin YS, Lee CY, Shao SC, Lai ECC. Comparison of adverse renal events between ranibizumab and aflibercept in patients with diabetic macular oedema: A global network study. Eye. 2026 Apr 22.

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  5. Su PH, Tsai DHT, Hsieh MH, Vairaperumal T, Lai ECC, Liu PY. Hyperuricemia risk in bempedoic acid-treated hyperlipidemic patients. Communications Medicine. 2026 Apr 1.

    Full text ↗ DOI ↗ JCR ↗ Open access

  6. Yang ASH, Fan Chiang HY, Tsai DHT, Chuang ATM, Lai ECC. Association Between Pneumonia Risk and Anticholinergic Burden Among Patients with Different Frailty Levels [Response to Letter]. Clinical Epidemiology. 2026 Apr 30;18:609824.

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  7. Drug Repurposing

    Shao SC, Tsai DHT, Chuang ATM, Liu KH, Lai ECC. SGLT2 inhibitors, GLP-1 RAs, and DPP4 inhibitors and the risk of hypomagnesemia in type 2 diabetes: A target trial emulation. PLOS Medicine. 2026 Mar 6;23(3):e1004968.

    Full text ↗ DOI ↗ JCR ↗ Open access

  8. Wei SY, Li BMH, Tsai DHT, Hu HY, Lin SY, Lin SJ, Su CC, Pan CH, Lai ECC. Association between venlafaxine use and the risk of withdrawal from nonopioid substances: a nationwide, population-based study. Harm Reduction Journal. 2026 Mar 2.

    Full text ↗ DOI ↗ JCR ↗ Open access

  9. Chuang LH, Tsai DHT, Chan YH, Shao SC, Lai CC, Lai ECC. Trends in First-Line Glaucoma Treatment from 2013 to 2024: A Multi-institutional and Multinational Cohort Study. Ophthalmology and Therapy. 2026 Feb 4.

    Full text ↗ DOI ↗ JCR ↗ Open access

  10. Lee WJA, Tsai DHT, Shao SC, Lai ECC. Intraocular inflammation incidence and real-world safety of intravitreal faricimab treatment across retinal indications. Naunyn-Schmiedeberg's Archives of Pharmacology. 2026 Jan 20.

    PubMed ↗ DOI ↗ JCR ↗
  11. Drug Repurposing

    Chou TS, Tsai DHT, Shao SC, Lai ECC. SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis. BMC Medicine. 2026 Jan 12.

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  12. Hsu HY, Chen KW, Lu HF, Chang SS, Tsai DHT, Lai ECC, Chang KC, Tsai FJ. Comparative Effectiveness of Clopidogrel vs. Potent P2Y12 Inhibitors in CYP2C19 Normal Metabolizers Following Percutaneous Coronary Intervention: A Real-World Cohort Study. British Journal of Clinical Pharmacology. 2026 Apr;92(4):1167-1176.

    PubMed ↗ DOI ↗ JCR ↗
  13. Drug Repurposing

    Liu CM, Tsai DHT, Tung HT, Lu ZH, Lai ECC, Liu CJ. Sodium-Glucose Cotransporter 2 Inhibitors Prevent Nephrolithiasis in Patients with Diabetes: A TriNetX-Based Real-World Global Comparison. Kidney360. 2026 Mar 1;7(3):633-641.

    Full text ↗ DOI ↗ JCR ↗ Open access
  14. Methodology

    Tsai DHT, Yang ASH, Wong ZX, Chuang ATM, Cheng MCY, Shen CY, Shao SC, Lai ECC. Antipsychotic therapy and suicide risk in patients with treatment-resistant depression: target trial emulation framework study. British Journal of Psychiatry. 2026 Jan;228(1):37-45.

    PubMed ↗ DOI ↗ JCR ↗

2025

  1. Shao SC, Tsai DHT, Li XW, Lai ECC. Association Between Sodium-Glucose Cotransporter 2 Inhibitors and Risk of Inflammatory Bowel Disease in Patients With Type 2 Diabetes Mellitus. Mayo Clinic Proceedings. 2025 Nov;100(11):2020-2023.

    PubMed ↗ DOI ↗ JCR ↗
  2. Data Infrastructure

    Hsieh CY, Shao SC, Sung SF, Hsieh MHC, Tsai DHT, Lin SJ, Lai ECC. Taiwan's National Health Insurance Research Database (NHIRD): in the Era of Artificial Intelligence, Causal Inference, and Data Security. Clinical Epidemiology. 2025 Nov 25;17:967-981.

    Full text ↗ DOI ↗ JCR ↗ Open access
  3. Polypharmacy

    Yang ASH, Fan Chiang HY, Tsai DHT, Chuang ATM, Lai ECC. Association Between Pneumonia Risk and Anticholinergic Burden Among Patients with Different Frailty Levels. Clinical Epidemiology. 2025 Sep 30;17:787-796.

    Full text ↗ DOI ↗ JCR ↗ Open access

  4. Yang ASH, Tsai DHT*, Chen LW, Cheng WM, Wang CC, Shao SC, Song WW, Kouhkamari MH, Huang WC, Bowditch S, Lai ECC. Epidemiology and Burden of Illness of Lennox-Gastaut Syndrome in Taiwan: A Retrospective Cohort Study. Risk Management and Healthcare Policy. 2025 Sep 20;18:3153-3166.

    Full text ↗ DOI ↗ JCR ↗ Open access
  5. Multinational Studies

    Ko HY, Au PCM, Cheng MCY, Cheung CL, Choi A, Hsieh MHC, Jeong HE, Lai ECC, Li BMH, Man KKC, Rassen JA, Tsai DHT, Wang SV, Wong ICK, Shin JY, Park S. Emulating Six Cardiovascular Outcome Trials of Antidiabetic Drugs in Individuals with Type 2 Diabetes: Analyses Based on Real-World Databases from Korea and Taiwan. Clinical Pharmacology & Therapeutics. 2025 Aug 17.

    Full text ↗ DOI ↗ JCR ↗ Open access

  6. Lin SS*, Tsai HH*, Tsai DHT*, Tsai CL, Itokazu N, Lin JG, Lai ECC, Lin HW, Hou YC. Prescription patterns of traditional Chinese medications and potential consequences in patients with new-onset cardiac or vascular-related diseases: a nationwide cohort study. BMC Complementary Medicine and Therapies. 2025 Jul 2;25(1):216.

    Full text ↗ DOI ↗ JCR ↗ Open access
  7. Global Disease Burden

    Tsai DHT, Wu ICY, Chang LF, Lu MJH, Debnath B, Govender NP, Sharland M, Warris A, Hsia Y, Ferreras-Antolin L. The burden of Neonatal Invasive Candidiasis in Low- and Middle-Income Countries: a systematic review and meta-analysis. Open Forum Infectious Diseases. 2025 Jun 11;12(7):ofaf329.

    Full text ↗ DOI ↗ JCR ↗ Open access

  8. Wei SY, Li BMH, Hu HY, Tsai DHT, Lin SJ, Lin SY, Su CC, Pan CH, Lai ECC. Detection of hidden populations using illicit substances. Journal of Epidemiology and Community Health. 2025 Aug 8;79(9):719-725.

    PubMed ↗ DOI ↗ JCR ↗

  9. Chuang ATM, Tsai DHT, Weng MY, Huang HK, Lai ECC. Effectiveness of JAK inhibitors in biologics-naïve patients with rheumatoid arthritis: a population-based study. Rheumatology. 2025 Aug 1;64(8):4668-4677.

    PubMed ↗ DOI ↗ JCR ↗
  10. Drug Repurposing

    Tsai DHT, Chuang ATM, Liu KH, Shao SC, Lai ECC. Sodium–glucose cotransporter 2 (SGLT2) inhibitors and risk of chronic kidney disease-mineral and bone disorders in patients with type 2 diabetes mellitus and stage 1–3 chronic kidney disease. CMAJ. 2025 Feb 23;197(7):E178-E189.

    Full text ↗ DOI ↗ JCR ↗ Open access

2024

  1. Lu KH, Hsieh CY, Tsai DHT, Lai ECC, Hsieh MT, Hsu WH, Lin KH. Association between dementia and left atrial appendage occlusion in patients with atrial fibrillation: A TriNetX-based retrospective cohort study with target trial emulation. Heart Rhythm O2. 2024 Nov 22;6(2):151-158.

    Full text ↗ DOI ↗ JCR ↗ Open access

  2. Tsai DHT, Harmon E, Goelen J, Barry HE, Chen LY, Hsia Y. Evaluating the Risk-Benefit Profile of Corticosteroid Therapy for COVID-19 Patients: A Scoping Review. Pharmacy. 2024 Aug 22;12(4):129.

    Full text ↗ DOI ↗ JCR ↗ Open access
  3. Drug Repurposing

    Hu JC, Shao SC, Tsai DHT, Chuang ATM, Liu KH, Lai ECC. Use of SGLT2 Inhibitors vs GLP-1 RAs and Anemia in Patients With Diabetes and CKD. JAMA Network Open. 2024 Mar 4;7(3):e240946.

    Full text ↗ DOI ↗ JCR ↗ Open access

2023

  1. Data Infrastructure

    Tsai DHT, Bell JS, Abtahi S, Baak BN, Bazelier MT, Brauer R, Chan AYL, Chan EW, Chen H, Chui CSL, Cook S, Crystal S, Gandhi P, Hartikainen S, Ho FK, Hsu ST, Ilomäki J, Kim JH, Klungel OH, Koponen M, Lau WCY, Lau KK, Lum TYS, Luo H, Man KKC, Pell JP, Setoguchi S, Shao SC, Shen CY, Shin JY, Souverein PC, Tolppanen AM, Wei L, Wong ICK, Lai ECC. Cross-Regional Data Initiative for the Assessment and Development of Treatment for Neurological and Mental Disorders. Clinical Epidemiology. 2023 Dec 21;15:1241-1252.

    Full text ↗ DOI ↗ JCR ↗ Open access
  2. Polypharmacy

    Huang WC, Yang ASH, Tsai DHT, Shao SC, Lin SJ, Lai ECC. Association between recently elevated anticholinergic burden and risk of acute cardiovascular events: A nationwide case-case-time-control study. The BMJ. 2023 Sep 27;382:e076045.

    Full text ↗ DOI ↗ JCR ↗ Open access

  3. Chan AYL, Yuen ASC, Tsai DHT, Lau WCY, Jani YH, Hsia Y, Osborn DPJ, Hayes JF, Besag FMC, Lai ECC, Wei L, Taxis K, Wong ICK, Man KKC. Gabapentinoid consumption in 65 countries and regions from 2008 to 2018: a longitudinal trend study. Nature Communications. 2023 Aug 17;14(1):5005.

    Full text ↗ DOI ↗ JCR ↗ Open access

  4. O'Sullivan C, Tsai DHT, Wu ICY, Boselli E, Hughes C, Padmanabhan D, Hsia Y. Machine learning applications on neonatal sepsis treatment: a scoping review. BMC Infectious Diseases. 2023 Jun 29;23(1):441.

    Full text ↗ DOI ↗ JCR ↗ Open access

  5. Tsai DHT, Chang WH, Lin HW, Lin SJ, Shao SC, Lai ECC. Post-discharge use of antipsychotics in patients with hospital-acquired delirium and associated risk of mortality - A population-based nested case-control study. Asian Journal of Psychiatry. 2023 May;83:103533.

    PubMed ↗ DOI ↗ JCR ↗

2019

  1. Yao SH*, Tsai HT*, Lin WL, Chen YC, Chou C, Lin HW. Predicting the serum digoxin concentrations of infants in the neonatal intensive care unit through an artificial neural network. BMC Pediatrics. 2019 Dec 27;19(1):517.

    Full text ↗ DOI ↗ JCR ↗ Open access